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Pharmacodynamic Models: Logarithmic Concentration–Effect Model01:15

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The log-linear model is a pharmacological framework used to describe the relationship between drug concentration and its effect. This model is particularly relevant when the observed effects range between 20% and 80% of the drug’s maximum effect (Emax), where a near-linear relationship is observed between the log of drug concentration and the measured effect. However, the log-linear model does not predict the maximum possible effect (Emax) or the effect at zero drug concentration,...
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Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
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The linear concentration–effect model, underpinned by the principle that pharmacological effect (E) is directly proportional to plasma drug concentration (C), emerges as a pivotal simplification of the Emax model for conditions where C is significantly less than EC50. This model portrays a linear trajectory of the concentration–effect relationship when drug levels are markedly below the EC50 threshold.Despite its inherent assumption of continuous effect augmentation with increasing...
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Related Experiment Video

Updated: May 5, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
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Technology diffusion in hospitals: a log odds random effects regression model.

Jos L T Blank1,2, Vivian G Valdmanis1,3

  • 1Institute for Public Sector Efficiency Studies, Delft University of Technology, Delft, The Netherlands.

The International Journal of Health Planning and Management
|December 11, 2013
PubMed
Summary
This summary is machine-generated.

Hospital innovation diffusion is influenced by size, competition, and commitment to innovation. Establishing an innovation office can improve technology adoption and efficiency.

Keywords:
diffusionhospitalslog odds regression modeltechnology

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Area of Science:

  • Health Services Research
  • Innovation Management
  • Health Economics

Background:

  • Understanding factors influencing the adoption of new technologies in hospitals is crucial for improving healthcare delivery.
  • Previous research has explored various determinants of innovation diffusion, but a comprehensive analysis using micro-level hospital data is needed.

Purpose of the Study:

  • To identify key factors affecting the diffusion of innovations within Dutch general hospitals.
  • To analyze the relationship between hospital characteristics and the adoption of new technologies.

Main Methods:

  • Application of a log odds random effects regression model on hospital micro data.
  • Analysis of data from 60 Dutch general hospitals between 1995 and 2002.
  • Distinguishing between service, physician, environmental, financial, and organizational determinants.

Main Results:

  • Hospital size, market competition, and a commitment to innovation positively influence the diffusion of innovations.
  • The study confirms existing research on determinants of innovation diffusion.
  • External effects of demand and market competition are critical for policy development.

Conclusions:

  • A direct relationship exists between identified determinants and the diffusion of hospital innovations.
  • Policies aimed at diffusing innovations should consider external market factors for efficient technology use.
  • Establishing an dedicated innovation office is recommended for individual hospitals to foster adoption.