Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Fibrinogen on Tenecteplase Treatment in Acute Ischaemic Stroke After 4.5 Hours of Symptom Onset: A Post Hoc Analysis of the TRACE-III Trial.

Neurology and therapy·2026
Same author

Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial.

JAMA·2026
Same author

RNS60 RESCUE Trial in Acute Ischemic Stroke: Post Hoc Analysis in Participants Enrolled <12 Hours Since Last Known Well.

Stroke (Hoboken, N.J.)·2026
Same author

Infarct growth rate and tenecteplase benefit in ischemic stroke at 4.5 to 24 h without thrombectomy-A secondary analysis of the TRACE-III randomized trial.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Antithrombotic strategies for the secondary prevention of stroke: A review.

The American journal of medicine·2026
Same author

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Sedation in Acute Ischemic Stroke: Pathophysiological Basis and Evidence for Commonly Used Agents.

Translational stroke research·2026
Same journal

Correction to: The Cerebrovascular Reactivity Adjusted Fractional Amplitude of Low-Frequency Fluctuations Abnormalities in Middle Cerebral Artery Stenosis and Occlusive Disease.

Translational stroke research·2026
Same journal

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Swallowing Function in Post-stroke Dysphagia: A Randomized Controlled Study.

Translational stroke research·2026
Same journal

Impact of Neutrophil Extracellular Traps on Clinical Outcome after Subarachnoid Hemorrhage: A Translational Narrative Review.

Translational stroke research·2026
Same journal

Multiscale Mechanisms that Underlie Intermittent Theta-burst Stimulation in Post-stroke Motor Recovery: From Molecular Signaling to Network Reorganization.

Translational stroke research·2026
Same journal

IGF-1 Inhibits the Hemodynamics‑Induced Progression of Intracranial Aneurysms by Modulating the Proliferation and Apoptosis of Vascular Smooth Muscle Cells.

Translational stroke research·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

6.5K

Imaging of experimental stroke models.

Marc Fisher1, Bernt Tore Bråtane

  • 1Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA, fisherm@ummhc.org.

Translational Stroke Research
|December 11, 2013
PubMed
Summary
This summary is machine-generated.

High-flow oxygen and neuroprotective drugs can preserve the ischemic penumbra, the target of acute stroke therapy. Advanced MRI techniques in animal models may extend the therapeutic window for stroke patients.

More Related Videos

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice
10:30

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Published on: October 20, 2016

22.1K
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.8K

Related Experiment Videos

Last Updated: May 5, 2026

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

6.5K
Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice
10:30

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Published on: October 20, 2016

22.1K
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.8K

Area of Science:

  • Neuroscience
  • Radiology
  • Pharmacology

Background:

  • The ischemic penumbra, a region of brain tissue at risk during stroke, is the primary target for acute stroke therapies.
  • Diffusion/perfusion MRI can approximate the penumbra by identifying areas with abnormal perfusion and normal diffusion.

Purpose of the Study:

  • To investigate the evolution of the diffusion/perfusion mismatch in rat stroke models.
  • To evaluate the effects of high-flow oxygen and neuroprotective agents on penumbral evolution.
  • To assess novel clot imaging techniques for stroke treatment.

Main Methods:

  • Utilized arterial spin labeling perfusion MRI and diffusion MRI in rat stroke models.
  • Administered high-flow oxygen and two neuroprotective drugs (Granulocyte colony stimulating factor, PSD95 inhibitor).
  • Employed a novel clot imaging technique combined with tPA and Annexin-2.

Main Results:

  • High-flow oxygen "froze" penumbral evolution, extending the therapeutic window for intravenous tissue plasminogen activator (tPA).
  • Neuroprotective drugs impeded the evolution of the diffusion/perfusion mismatch into infarction.
  • The combination of tPA plus Annexin-2 was more effective than tPA alone in dissolving emboli and reducing hypoperfused brain tissue.

Conclusions:

  • Advanced MRI techniques in animal models are crucial for understanding penumbral dynamics.
  • Interventions like high-flow oxygen and specific drugs show potential in preserving the ischemic penumbra.
  • These findings may contribute to extending the therapeutic time window for acute ischemic stroke patients.