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Minoxidil in severe hypertension.

M Oka, M Mäkelä

    Acta Medica Scandinavica
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Minoxidil effectively lowered blood pressure in patients with severe hypertension and renal failure resistant to other drugs. While side effects like hirsutism occurred, it arrested hypertensive organ damage and prevented major vascular events.

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    Area of Science:

    • Nephrology
    • Cardiology
    • Pharmacology

    Background:

    • Severe hypertension with renal failure poses significant treatment challenges.
    • Patients often exhibit resistance to conventional antihypertensive therapies.
    • Minoxidil is a potent vasodilator considered for refractory cases.

    Purpose of the Study:

    • To evaluate the efficacy and safety of minoxidil in patients with severe hypertension and renal failure.
    • To assess the impact of minoxidil on blood pressure control and hypertensive organ damage.
    • To identify common side effects and contraindications for minoxidil use in this population.

    Main Methods:

    • Minoxidil was administered to 16 patients with severe hypertension and renal failure.
    • Treatment was combined with beta-blockers and diuretics or dialysis.

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  • Patients were monitored for blood pressure changes, organ damage progression, and adverse events over an average of 12 months.

    • Main Results:

    • Average supine blood pressure decreased from 200/130 to 164/96 mmHg; upright BP from 200/120 to 152/90 mmHg.
    • Progression of hypertensive organ changes was arrested in most patients.
    • Common side effects included skin prickling and hirsutism; edema and latent diabetes were also observed.

    Conclusions:

    • Minoxidil is an effective treatment for severe, drug-resistant renal hypertension.
    • While side effects exist, minoxidil can halt hypertensive organ damage and prevent vascular complications.
    • Hirsutism is a notable side effect, potentially contraindicating long-term use in female patients.