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Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

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A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
55
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
482
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54

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Related Experiment Video

Updated: May 5, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

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Review of stroke thrombolytics.

Andrew Bivard1, Longting Lin, Mark W Parsonsb

  • 1Departments of Neurology and Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Journal of Stroke
|December 11, 2013
PubMed
Summary

Rapid reperfusion therapy for acute ischemic stroke is crucial. Newer agents like Tenecteplase and advanced imaging show promise for improved outcomes and extended treatment windows.

Area of Science:

  • Neuroscience
  • Cerebrovascular Medicine
  • Emergency Medicine

Background:

  • Acute ischemic stroke treatment focuses on rapid thrombus removal.
  • Current guidelines recommend intravenous alteplase within 4.5 hours.
  • Limitations include short time windows, hemorrhage risk, and efficacy for large clots.

Purpose of the Study:

  • To explore novel and safer reperfusion therapies for acute ischemic stroke.
  • To refine patient selection for acute reperfusion treatments.
  • To investigate advanced imaging techniques for extended therapeutic windows.

Main Methods:

  • Review of studies on advanced imaging (perfusion CT, diffusion/perfusion MRI).
  • Analysis of clinical trials comparing Tenecteplase with alteplase.
Keywords:
Ischemic strokeStroke trialsThrombolysis

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  • Exploration of Desmoteplase efficacy in specific patient subgroups.
  • Investigation of endovascular therapy and sono-thrombolysis.

    • Main Results:

    • Tenecteplase with advanced imaging demonstrated more effective reperfusion and clinical benefit than alteplase.
    • Desmoteplase showed potential benefit in patients with large artery occlusion and salvageable tissue.
    • Advanced imaging may enable thrombolytics or endovascular therapy in extended time windows.

    Conclusions:

    • Advanced imaging and newer thrombolytic agents like Tenecteplase offer improved outcomes for acute ischemic stroke.
    • Further research into patient selection and novel reperfusion strategies is essential.
    • Potential exists for extending treatment windows with advanced imaging guidance.