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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Association of aortic knob calcification with intracranial stenosis in ischemic stroke patients

Young Seo Kim1, Hyun Young Park, Kyeong-Ho Yun

  • 1Department of Neurology, Wonkwang University School of Medicine, Wonkwang Institute of Clinical Medicine, Iksan, Korea.

Journal of Stroke
|December 11, 2013
PubMed

Insights

Aortic knob calcification (AC) on chest X-rays reliably predicts intracranial stenosis in ischemic stroke patients. This simple, non-invasive method aids in identifying stroke mechanisms.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Aortic knob calcification (AC) is linked to cardiovascular and cerebrovascular events.
  • Intracranial (IC) stenosis is a significant cause of ischemic stroke.

Purpose of the Study:

  • To assess the clinical importance of AC in predicting IC stenosis in ischemic stroke patients.
  • To utilize routine chest radiography for non-invasive AC evaluation.

Main Methods:

  • AC presence was evaluated on chest posteroanterior views in 307 acute ischemic stroke patients.
  • Patients underwent magnetic resonance angiography or distal subtraction angiography.
  • The association between AC and IC stenosis was analyzed.

Main Results:

  • Patients with AC were older and had a higher prevalence of IC stenosis (70.7% vs. 41.3%).
  • Logistic regression revealed AC (OR, 3.54) and age (OR, 1.79) as independent predictors of IC stenosis after adjusting for risk factors.

Conclusions:

  • Aortic knob calcification is a dependable predictor of intracranial stenosis.
  • AC can help identify a key mechanism in ischemic stroke.
Abstract

Keywords:
Aortic knob calcificationAtherosclerosisIschemic stroke

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