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Related Experiment Videos

Rate responsive pacemakers: assessment after two years.

M Zegelman, F Beyersdorf, J Kreuzer

    Pacing and Clinical Electrophysiology : PACE
    |November 1, 1986
    PubMed
    Summary

    Rate responsive pacemakers (RRPM) improve exercise capacity by increasing heart rate (HR). These devices demonstrated reliable performance and enhanced cardiac output (CO) during exercise in patients with insufficient HR response.

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    Area of Science:

    • Cardiology
    • Biomedical Engineering

    Background:

    • Patients with insufficient heart rate (HR) response to exercise may have limited cardiac output (CO) and exercise capacity.
    • Rate responsive pacemakers (RRPM) offer a potential solution by increasing HR during physical activity.

    Purpose of the Study:

    • To evaluate the efficacy and reliability of different types of rate responsive pacemakers (RRPM).
    • To assess the impact of RRPM on cardiac output (CO) and exercise capacity.

    Main Methods:

    • Implantation of 30 QT-related (TX), 25 respiratory dependent (RDP), and 35 body activity directed (ACT) pacemakers between 1983 and 1985.
    • Follow-up included Holter-ECG, exercise testing (treadmill/bicycle/climbing step), and determination of CO using thermodilution or radionuclide ventriculography.

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    Main Results:

    • All tested RRPM systems (TX, RDP, ACT) showed adaptation of HR during exercise.
    • Significant increases in CO during exercise were observed with TX (delta = 1.7 l/min) and RDP (delta = 2.1 l/min) compared to VVI-mode.
    • Despite individual system weaknesses, RRPM were found to be reliable devices.

    Conclusions:

    • Rate responsive pacemakers are effective in improving exercise capacity for patients with inadequate HR response.
    • RRPM are reliable devices that can enhance cardiac output during physical exertion.
    • The study supports the continued use of RRPM in clinical practice.