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[Risk factors associated with cardiac involvement in patients with dermatomyositis/polymyositis]

Chuan Zuo1, Xuan-Di Wei, Ya-Li Ye

  • 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|December 12, 2013
PubMed

Insights

Cardiac involvement is common in dermatomyositis/polymyositis, often subclinical. Interstitial lung disease, positive ANA, older age, and AST/CK ratio predict cardiac complications in these patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Internal Medicine

Context:

  • Dermatomyositis/polymyositis (DM/PM) are inflammatory myopathies with potential systemic manifestations.
  • Cardiac involvement (CI) is a significant, though often underdiagnosed, complication in DM/PM patients.
  • Identifying predictors of CI is crucial for early detection and management.

Purpose:

  • To identify risk factors associated with cardiac involvement (CI) in patients diagnosed with dermatomyositis/polymyositis (DM/PM).

Summary:

  • This retrospective study analyzed 129 DM/PM patients, finding CI in 45.74%. Key predictors identified through logistic regression included interstitial lung disease, elevated aspartic aminotransferase/creatine kinase (AST/CK) ratio, positive antinuclear antibody (ANA), and older age.
  • Electrocardiogram (ECG) and ultrasonic cardiogram (UCG) are common diagnostic tools, with the AST/CK ratio showing potential as a predictive marker for CI.

Impact:

  • The findings highlight that interstitial lung disease, a positive ANA, older age, and the AST/CK ratio are significant predictors of cardiac involvement in DM/PM.
  • Early identification of these risk factors can facilitate timely intervention and improve patient outcomes in DM/PM.
Abstract

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