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Updated: May 5, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats
Qin Zhang1, Kelly J Davis, Dana Hoffmann
1Center for Devices & Radiological Health, US FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Aims:
To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity.
Materials & Methods:
A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats.
Results:
Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats.
Conclusion:
Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.
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