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Fibrinolytic therapy in patients with ST-elevation myocardial infarction

Amirreza Solhpour1, Syed W Yusuf

  • 1Department of Cardiology, University of Texas Health Science Center at Houston and Memorial Hermann Heart and Vascular Institute, Houston, 77030-1503 TX, USA.

Expert Review of Cardiovascular Therapy
|December 12, 2013
PubMed

Insights

Fibrinolysis remains crucial for ST-elevation myocardial infarction (STEMI) reperfusion when primary percutaneous coronary intervention (PCI) is delayed. This review highlights fibrinolysis

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Pharmacology

Background:

  • ST-elevation myocardial infarction (STEMI) results from acute coronary artery occlusion.
  • Early reperfusion is vital for reducing infarct size and improving STEMI patient prognosis.

Purpose of the Study:

  • To review the role and importance of fibrinolytic agents in STEMI reperfusion therapy.
  • To discuss the clinical efficacy and administration of fibrinolysis when primary PCI is not feasible within recommended timeframes.

Main Methods:

  • Literature review focusing on fibrinolysis in STEMI.
  • Analysis of reperfusion strategies, including percutaneous coronary intervention (PCI) and fibrinolytic agents.

Main Results:

  • Primary PCI is the preferred reperfusion method for STEMI when timely.
  • Fibrinolysis remains a key reperfusion strategy for STEMI patients unable to access timely primary PCI due to logistical constraints.

Conclusions:

  • Fibrinolysis is an essential treatment modality for STEMI, particularly in settings where primary PCI is not immediately available.
  • The clinical efficacy and ease of administration support the continued use of fibrinolysis in STEMI management.

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