Tacrolimus-loaded PLGA implants: in vivo release and ocular toxicity
Related Experiment Video
Updated: May 5, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Marcela C M Souza1, Sílvia L Fialho, Pedro A F Souza
1Faculty of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil .
Purpose:
To evaluate the in vivo release and ocular toxicity of a tacrolimus-loaded PLGA intravitreal implant.
Methods:
Tacrolimus-loaded PLGA implants were inserted into the vitreous cavity of rabbits' eye. At different time points, the vitreous was retrieved and the concentration of tacrolimus released from the implants was determined. Clinical examination was performed to evaluate the implant tolerance.
Results:
PLGA implants provided controlled and prolonged release of tacrolimus. Approximately 99.97% of the drug was released from the devices at 6 weeks. Ophthalmic examination revealed no evidence of toxic effects of implants.
Conclusions:
Tolerance and feasibility of the tacrolimus-loaded PLGA implants, as sustained intraocular drug delivery systems, were demonstrated.
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