Related Experiment Video
Updated: May 5, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
Periorbital dermatitis in 4779 patients - patch test results during a 10-year period
Lilla Landeck1, Swen M John, Johannes Geier
1Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, 49090, Germany.
Background:
The thinness of the periorbital skin may facilitate allergen penetration, making this area particularly susceptible to sensitization.
Material And Methods:
For the cross-sectional study, data were collected by the 57 participating centres of the Information Network of Departments of Dermatology. A total of 101 403 patients patch tested between January 2001 and December 2010 were included. Of these, 4779 patients suffered from periorbital dermatitis.
Results:
Two major subgroups with different general epidemiological data and sensitization to specific allergens have to be considered: (i) young females with increased rates of skin atopy and allergies, particularly from cosmetic and skin care products; and (ii) older subjects with allergy to topical medications. The prevalence of sensitization to ophthalmic allergens is generally less than that to environmental allergens.
Conclusions:
Allergic contact dermatitis is a leading cause of periorbital dermatitis. Patch testing should be considered in all patients with periorbital dermatitis when contact allergy is suspected, in order to identify and avoid offending allergens.

