Is there a need to redefine the diagnostic criteria for common variable immunodeficiency?
Mikko Seppänen1, Asghar Aghamohammadi, Nima Rezaei
1Department of Medicine, Division of Infectious Diseases, Immunodeficiency Unit, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.
Abstract:
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased serum levels of immunoglobulins and abnormal antibody response to protein and/or polysaccharide antigens, leading to recurrent respiratory and gastrointestinal infections, autoimmunity and malignancies. Meanwhile, several monogenic defects with CVID-like phenotype have been identified during the last decade. There is a need to reach international consensus by modifying criteria for CVID, considering various areas of uncertainty in the field.
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