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Canalicular adenoma immunoprofile: a case report
Stefano Sivolella1, Marialuisa Valente, Marleen De Biagi
1Institute of Clinical Dentistry, Department of Neurosciences, Neurological, Psychiatric, Sensorial, Reconstructive and Rehabilitative Sciences, University of Padova, Padova, Italy.
Gerodontology
|December 12, 2013
Summary
This case report highlights canalicular adenoma (CA), a rare benign salivary gland tumor. Immunohistochemistry aids in confirming the diagnosis of this oral cavity neoplasm.
Area of Science:
- Oral Pathology
- Surgical Pathology
- Oncology
Background:
- Canalicular adenoma (CA) is an uncommon benign neoplasm originating from minor salivary gland duct tissues.
- Histological features of CA can overlap with other salivary gland tumors, necessitating precise diagnostic methods.
- Immunohistochemistry plays a crucial role in differentiating CA from other salivary neoplasms.
Observation:
- A case of canalicular adenoma presented as a nodule on the upper lip of an 85-year-old male.
- The patient's primary concern was denture instability due to soft tissue changes.
- The lesion was surgically excised for histological and immunohistochemical analysis to exclude malignancy.
Findings:
- Histological examination revealed findings consistent with a benign salivary tumor.
- Cytokeratin positivity confirmed the epithelial origin of the lesion.
- Absence of reactivity to myoepithelial markers supported the diagnosis of canalicular adenoma.
Implications:
- Immunohistochemistry is a valuable tool for confirming the histological diagnosis of canalicular adenoma.
- Accurate diagnosis of benign salivary tumors like CA is essential for appropriate patient management.
- This case underscores the utility of immunohistochemistry in challenging differential diagnoses of salivary gland lesions.
