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Updated: May 5, 2026
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans
Romel D Mackelprang1, Abigail W Bigham, Connie Celum
1Department of Global Health.
Objective:
We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.
Methods:
Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.
Results:
TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.
Conclusions:
TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.
