Related Experiment Video
Updated: May 5, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts
Hiromi Sesaki1, Yoshihiro Adachi1, Yusuke Kageyama1
1Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress in mitochondrial division by focusing on molecular and in vivo analyses of the evolutionarily conserved, central component of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms.

