Synthesis and insecticidal evaluation of novel anthranilic diamides containing N-substitued nitrophenylpyrazole
Xiulan Zhang1, Yuxin Li1, Jinlong Ma1
1State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
Abstract:
To cope with developing pest resistance and ecological problems associated with conventional insecticides and to search for potent insecticides targeting at ryanodine receptor (RyR), a series of novel anthranilic diamides containing N-substitued nitrophenylpyrazole were designed and synthesized. The insecticidal activities of target compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated in our greenhouse by bio-assay tests and the relative structure-activity relationships were briefly discussed. Most compounds exhibited moderate to high activities, in which G₇ and K₅ showed high activity against oriental armyworm and K₂ and K₄ against diamondback moth even better than the control-chlorantraniliprole. The calcium imaging technique was used to investigate the effects of several typical title compounds on the [Ca(2+)](i), especially the effects of G₇ on the intracellular calcium ion concentration ([Ca(2+)](i)) in neurons, which indicated that some title compounds were potent activators of the RyR.
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