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Glioblastoma, brain metastases and soft tissue sarcoma of extremities: candidate tumors for BNCT
Andrea Wittig1, Raymond L Moss2, Wolfgang A G Sauerwein3
1Department of Radiotherapy and Radiation Oncology, Pilipps-University Marburg, Marburg, Germany.
Abstract:
(10)B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for preferential (10)B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean (10)B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising targets for future BNCT research.
