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A novel (99m)Tc labelling strategy for the development of silica based particles for medical applications
Michel A Wuillemin1, Wanda T Stuber, Thomas Fox
1Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. braband@aci.uzh.ch.
Dalton Transactions (Cambridge, England : 2003)
|December 12, 2013
Abstract:
The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.
