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Updated: Sep 21, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
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Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 22, 2012

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MicroRNAs in normal and psoriatic skin

Jing Xia1, Weixiong Zhang

  • 1Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China;

Physiological Genomics
|December 12, 2013
PubMed

Insights

MicroRNAs are key regulators in skin development and disease. This review covers microRNA discovery and function in psoriasis, a chronic skin condition.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Gene Regulation

Background:

  • Psoriasis is a chronic, incurable skin disorder characterized by inflammatory lesions and altered gene expression.
  • MicroRNAs (miRNAs) are critical posttranscriptional regulators involved in skin development and disease.
  • Dysregulated miRNA expression is increasingly recognized in psoriatic skin.

Purpose of the Study:

  • To review recent advancements in the discovery, profiling, and characterization of microRNAs in human psoriatic skin.
  • To discuss the biological functions and regulatory roles of microRNAs in the context of psoriasis.
  • To highlight current challenges and future directions in microRNA research for psoriasis.

Main Methods:

  • Literature review of recent studies on microRNAs in psoriasis.
  • Analysis of gene expression data related to microRNAs in psoriatic skin.
  • Synthesis of current knowledge on microRNA discovery and functional characterization.

Main Results:

  • Numerous novel microRNAs have been identified in skin.
  • Significant dysregulation of microRNA expression and function has been observed in psoriasis.
  • MicroRNA-mediated gene regulation demonstrates robustness and plasticity in psoriatic skin.

Conclusions:

  • MicroRNAs play a significant role in the pathogenesis of psoriasis.
  • Further research into microRNA functions and therapeutic potential is warranted.
  • Understanding microRNA regulation is crucial for addressing challenges in psoriasis treatment.
Keywords:
endogenous siRNAmicroRNApsoriasisskin development

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