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B7-H4 expression in normal and diseased human islet β cells

Susan S C Cheung1, Dawei Ou, Daniel L Metzger

  • 1From the Departments of *Surgery and †Paediatrics, Faculty of Medicine, ‡Department of Experimental Therapeutics, Faculty of Pharmaceutical Sciences, University of British Columbia; and §British Columbia Cancer Agency; and ∥Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Pancreas
|December 12, 2013
PubMed
Summary

Altered B7-H4 expression in pancreatic islets is linked to type 1 diabetes (T1D), pancreatic ductal adenocarcinoma (PDAC), and insulinoma. This suggests B7-H4 plays a role in beta-cell function.

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