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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Microscopic Anatomy of Skeletal Muscles01:13

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Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
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Related Experiment Video

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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Myositis ossificans: the mimicker.

Arunkumar Govindarajan1, Radha Sarawagi, Manikka Lakshmanan Prakash

  • 1Department of Radiology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

BMJ Case Reports
|December 12, 2013
PubMed
Summary

This case study highlights myositis ossificans, a condition causing painful swelling and backache in adolescents. Imaging like CT scans confirmed the diagnosis by showing characteristic calcification development.

Area of Science:

  • Radiology
  • Orthopedic Surgery
  • Pediatric Case Study

Background:

  • Myositis ossificans is a benign condition involving heterotopic bone formation in muscle.
  • Early diagnosis is crucial for appropriate management and to differentiate from malignant tumors.

Observation:

  • A 14-year-old male presented with acute onset upper backache and a painful paraspinal swelling.
  • Initial MRI revealed a non-specific lesion with intense enhancement.
  • Ultrasound and CT demonstrated peripheral calcification evolving over time.

Findings:

  • The imaging findings, particularly the progressive rim calcification on CT, were diagnostic of myositis ossificans.
  • The case underscores the importance of serial imaging in diagnosing evolving musculoskeletal lesions.

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  • Differential diagnoses included soft tissue tumors and infections.

    • Implications:

    • This case emphasizes the utility of advanced imaging techniques in diagnosing myositis ossificans.
    • Understanding the imaging spectrum of myositis ossificans aids in accurate diagnosis and avoids unnecessary interventions.
    • Further research into the pathogenesis and optimal treatment strategies for myositis ossificans is warranted.