Related Experiment Video
Updated: May 5, 2026
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
Characteristics and outcomes of patients with multiple cervical artery dissection
Yannick Béjot1, Corine Aboa-Eboulé, Stéphanie Debette
1From the Department of Neurology, Dijon University Hospital, Dijon, France (Y.B., C.A.-E., M.G.); Department of Epidemiology and Public Health, Inserm U744, Pasteur Institute, Lille, France (S.D., J.D.); Department of Neurology, EA1046, Lille University Hospital, Lille, France (S.D., D.L.); Department of Clinical and Experimental Sciences, Neurology Clinic, Brescia University Hospital, Brescia, Italy (A.P.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (T.T., T.M., A.M.); Department of Neurology, University Hospital of Basel, Basel, Switzerland (S.E., P.L.); Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany (C.G.-G., M.K.); Department of Neurology, Sainte-Anne University Hospital, Paris, France (E.T.); Department of Neurology, San Raffaele University Hospital, Milan, Italy (M.S.); Stroke Unit, Perugia University Hospital, Italy (V.C.); and Laboratory of Experimental Neurology, Université Libre de Bruxelles, Brussels, Belgium (M.P., S.A.).
Insights
Multiple cervical artery dissections (CeAD) are linked to specific triggers like infection and manipulation, and underlying conditions such as fibromuscular dysplasia. However, multiple CeAD does not worsen short-term outcomes compared to single CeAD.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Research
Background:
- Limited understanding of factors differentiating single from multiple cervical artery dissections (CeAD).
- Need to clarify prognostic differences between single and multiple CeAD events.
Purpose of the Study:
- To compare baseline characteristics of patients with multiple versus single CeAD.
- To evaluate the short-term prognosis associated with multiple CeAD.
Main Methods:
- Analysis of data from the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study.
- Comparison of 149 patients with multiple CeAD against those with single CeAD (983 total CeAD patients).
Main Results:
- Multiple CeAD associated with cervical pain, prior head/neck surgery, recent infection, and cervical manipulation.
- Fibromuscular dysplasia and pseudoaneurysms were more frequent in multiple CeAD cases.
- No significant difference in 3-month functional outcome between multiple and single CeAD groups.
Conclusions:
- Identified distinct features associated with multiple CeAD, including vasculopathy indicators and environmental triggers.
- Multiple CeAD is linked to specific risk factors but shares similar short-term prognosis with single CeAD.
Background And Purpose:
Little is known about factors contributing to multiple rather than single cervical artery dissections (CeAD) and their associated prognosis.
Methods:
We compared the baseline characteristics and short-term outcome of patients with multiple to single CeAD included in the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study.
Results:
Among the 983 patients with CeAD, 149 (15.2%) presented with multiple CeAD. Multiple CeADs were more often associated with cervical pain at admission (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.10-2.30), a remote history of head or neck surgery (OR, 1.87; 95% CI, 1.16-3.00), a recent infection (OR, 1.71; 95% CI, 1.12-2.61), and cervical manipulation (OR, 2.23; 95% CI, 1.26-3.95). On imaging, cervical fibromuscular dysplasia (OR, 3.97; 95% CI, 2.04-7.74) and the presence of a pseudoaneurysm (OR, 2.91; 95% CI, 1.86-4.57) were more often seen in patients with multiple CeAD. The presence of multiple rather than single CeAD had no effect on functional 3-month outcome (modified Rankin Scale score, ≥3; 12% in multiple CeAD versus 11.9% in single CeAD; OR, 1.20; 95% CI, 0.60-2.41).
Conclusions:
In the largest published series of patients with CeAD, we highlighted significant differences between multiple and single artery involvement. Features suggestive of an underlying vasculopathy (fibromuscular dysplasia) and environmental triggers (recent infection, cervical manipulation, and a remote history of head or neck surgery) were preferentially associated with multiple CeAD.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
01:26Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
01:22Aneurysm IV: Nursing Management