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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
236
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Related Experiment Video

Updated: May 4, 2026

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction
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Cutaneous drug delivery: an update.

Thanh-Nga T Tran1

  • 1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.

The Journal of Investigative Dermatology. Symposium Proceedings
|December 12, 2013
PubMed
Summary
This summary is machine-generated.

Developing effective cutaneous drug delivery is challenging due to the skin's barrier. Overcoming the stratum corneum barrier safely is key for delivering hydrophilic therapeutics for dermatologic conditions.

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Area of Science:

  • Dermatology
  • Pharmaceutics
  • Biomedical Engineering

Background:

  • Cutaneous drug delivery offers a targeted approach for dermatologic conditions with reduced systemic effects.
  • The stratum corneum presents a significant permeability barrier, limiting the efficacy of many topical treatments.
  • Innovations in drug delivery systems have not fully overcome the stratum corneum's resistance to drug penetration.

Purpose of the Study:

  • To address the challenge of delivering large hydrophilic drugs through the skin.
  • To explore safe and reversible methods for overcoming the stratum corneum barrier.
  • To advance the field of dermatologic therapy through improved cutaneous drug delivery.

Main Methods:

  • Investigating novel strategies to enhance skin permeability.
  • Evaluating the safety and reversibility of barrier disruption techniques.
  • Assessing the delivery efficiency of large hydrophilic molecules via the cutaneous route.

Main Results:

  • The stratum corneum barrier significantly impedes the transdermal transport of therapeutics.
  • Current drug delivery innovations face limitations in penetrating the skin's outer layer.
  • Safe and reversible methods for overcoming the skin barrier are crucial for effective cutaneous drug delivery.

Conclusions:

  • Overcoming the stratum corneum barrier is essential for successful cutaneous drug delivery.
  • Further research is needed to develop advanced systems for delivering hydrophilic drugs topically.
  • Advancements in this area promise improved treatments for various dermatologic conditions.