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Serum Eosinophilic Cationic Protein (ECP) in Asthmatic Malaysian Children

P W K Chan1, H H Samsinah, H Z Arpin

  • 1University Hospital, Department of Paediatrics, 50603 Kuala Lumpur, Malaysia.

The Medical Journal of Malaysia
|December 12, 2013
PubMed

Insights

Serum eosinophilic cationic protein (ECP) levels were significantly higher in asthmatic children compared to controls. Elevated ECP may aid in diagnosing childhood asthma in Malaysia.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Eosinophilic inflammation is a key factor in childhood asthma development.
  • Serum eosinophilic cationic protein (ECP) serves as a reliable marker for eosinophil activation.

Purpose of the Study:

  • To investigate serum ECP levels in children with asthma.
  • To assess the utility of serum ECP as a diagnostic marker for childhood asthma in Malaysia.

Main Methods:

  • Serum ECP was measured in 20 asthmatic children and 19 non-asthmatic controls.
  • Demographic data, passive smoke exposure, urinary cotinine, and family history were compared between groups.

Main Results:

  • No significant differences were found in socio-demographics, smoke exposure, or family history between groups.
  • Median serum ECP was significantly higher in asthmatic children (27.0 mcg/L) versus controls (5.9 mcg/L), with p=0.002.

Conclusions:

  • Serum ECP levels are elevated in children with asthma.
  • Elevated serum ECP can provide supportive evidence for diagnosing childhood bronchial asthma in the Malaysian population.

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