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Related Experiment Video

Updated: May 4, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Multiple organ dysfunction caused by parathyroid adenoma-induced primary hyperparathyroidism.

Q-Y Fu¹, L Ma, Z-B Yang

¹Treatment Center for Kidney Diseases, No. 281 Hospital of Chinese People's Liberation Army, 4 Xi hai tan Road, Beidaihe District, Qinhuangdao 066100, P. R, China.

Nigerian Journal of Clinical Practice

|December 12, 2013

Summary

A parathyroid adenoma caused primary hyperparathyroidism (PHPT) leading to multi-organ dysfunction. Surgical removal normalized calcium but renal insufficiency persisted, highlighting PHPT

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Area of Science:

Endocrinology
Nephrology
Pathology

Background:

Primary hyperparathyroidism (PHPT) can lead to severe hypercalcemia and multi-organ complications.
Parathyroid adenoma is the most common cause of PHPT.

Observation:

A 27-year-old male presented with acute gastrointestinal symptoms, polyuria, polydipsia, bone pain, renal dysfunction, nephrolithiasis, and pancreatitis.
Biochemical tests and renal biopsy confirmed PHPT with acute tubular injury and significant calcium deposition.
Neck ultrasonography indicated a parathyroid tumor, later confirmed as an adenoma post-excision.

Findings:

Surgical removal of the parathyroid adenoma normalized serum calcium levels.
Despite normalized calcium, the patient remained renally insufficient, with repeat biopsy showing chronic renal tubular injury.
This case demonstrates the diverse systemic complications of PHPT secondary to parathyroid adenoma.

Implications:

Parathyroid adenoma can cause severe, multi-systemic disease, including renal impairment.
Early diagnosis and surgical intervention are crucial for managing PHPT complications.
Long-term renal function monitoring is essential even after successful parathyroidectomy in PHPT patients.