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Published on: May 6, 2014
[Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease]
1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, P.R. China. xlx77471@163.com.
Objective:
To assess the association of interleukin 10 (IL10) gene -592C/A polymorphism with morbidity of coronary heart disease in a southern Chinese Han population.
Methods:
Frequencies of various genotypes and alleles for the IL10 -592C/A polymorphism (rs1800872) were determined by the means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in 249 patients and 132 unaffected controls.
Results:
The frequencies of both IL10 -592C/A site and different alleles have reached statistical significance (P<0.05) after correcting the difference in clinical data by logistic regression analysis. The risk of coronary heart disease in the patients with A gene (AA+CA) was 2.449 times greater than those without (95%CI:1.214-4.940, P=0.012).
Conclusion:
IL10 gene -592C/A polymorphism is associated with the risk of coronary heart disease. Allele A may be a risk factor for this disease in the studied population.
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