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Advances in systemic therapy for advanced pancreatobiliary malignancies
Thorvardur R Halfdanarson1, Sigurdis Haraldsdottir, Mitesh J Borad
1Division of Hematology and Medical Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
F1000Research
|December 12, 2013
Summary
Pancreatobiliary cancers have a poor prognosis despite recent treatment advances. This review covers current options for advanced disease and highlights novel targeted therapies for improved patient outcomes.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Pancreatobiliary malignancies are rare cancers with a generally poor prognosis.
- Current treatment for advanced stages involves systemic therapy (metastatic) or combined systemic and radiation therapy (locally advanced, unresectable).
Approach:
- This review examines current therapeutic strategies for locally advanced pancreatobiliary cancers.
- It highlights recent progress in systemic treatments, focusing on novel targeted therapies.
Key Points:
- Despite advances, patient survival for pancreatobiliary cancers remains limited.
- Targeted treatments represent a promising area for improving outcomes in advanced disease.
Conclusions:
- Effective management of locally advanced pancreatobiliary malignancies requires a comprehensive approach.
- Ongoing research into targeted therapies is crucial for enhancing treatment efficacy and patient survival.
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