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Updated: May 4, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Complementary strategies for developing Gd-free high-field T₁ MRI contrast agents based on Mn(III) porphyrins
Weiran Cheng1, Inga E Haedicke, Joris Nofiele
1Department of Chemistry, University of Toronto , Toronto, Ontario, M5S 3H6, Canada.
Abstract:
Mn(III) porphyrin (MnP) holds the promise of addressing the emerging challenges associated with Gd-based clinical MRI contrast agents (CAs), namely, Gd-related adverse effect and decreasing sensitivity at high clinical magnetic fields. Two complementary strategies for developing new MnPs as Gd-free CAs with optimized biocompatibility were established to improve relaxivity or clearance rate. MnPs with distinct and tunable pharmacokinetic properties can consequently be constructed for different in vivo applications at clinical field of 3 T.
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