Related Experiment Video

Updated: May 4, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

11.7K

ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysis

Yuanzhe Jin1, Qi Wang, Guofeng Wang

  • 1Department of Cardiology, The Fourth Affiliated Hospital of China Medical University , Shenyang, People's Republic of China .

Genetic Testing and Molecular Biomarkers
|December 17, 2013
PubMed

Insights

The ABCB1 C3435T gene polymorphism is linked to a higher risk of coronary heart disease (CHD), particularly myocardial infarction and acute coronary syndrome in Caucasians. This genetic marker may aid in early CHD detection.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Pharmacogenomics

Background:

  • ATP-binding cassette transporter 1 (ABCB1) is crucial in cardiovascular disease.
  • Functional polymorphisms in the ABCB1 gene may influence coronary heart disease (CHD) susceptibility.
  • Previous studies on ABCB1 C3435T polymorphism and CHD risk are inconclusive.

Purpose of the Study:

  • To conduct a meta-analysis to precisely estimate the association between ABCB1 C3435T polymorphism and CHD risk.
  • To investigate the impact of this polymorphism on different subtypes of CHD and across ethnic groups.

Main Methods:

  • An extensive literature search was performed across multiple databases up to August 1, 2013.
  • Meta-analysis was conducted using STATA 12.0 software.
  • Crude odds ratios (OR) with 95% confidence intervals (CI) were calculated.

Main Results:

  • Seven studies with 13,074 CHD patients were included.
  • ABCB1 C3435T polymorphism was associated with increased risk of CHD, especially myocardial infarction (MI) and acute coronary syndrome (ACS) in Caucasians.
  • No significant association was found for variant angina pectoris (VAP) risk, particularly in Asians. Heterogeneity was attributed to clinical subtype and ethnicity.

Conclusions:

  • ABCB1 C3435T polymorphism may contribute to CHD risk, particularly MI and ACS in Caucasian populations.
  • This genetic polymorphism shows potential as a biomarker for early CHD detection.
  • Further research may clarify ethnic and subtype-specific associations.
Abstract

More Related Videos

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

23.8K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
890
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
159
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
189