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Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization

Sabna Kotta¹, Abdul Wadood Khan, S H Ansari

¹Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard , New Delhi , India and.

|December 17, 2013

Summary

This study compares high-energy and low-energy nanoemulsion production methods. While globule size was similar, low-energy methods showed significant differences in poly-dispersibility index and drug release rates.

Keywords:

Condensation method high-energy emulsification low-energy method nanoemulsion phase inversion composition

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Published on: September 13, 2012

Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Nanoemulsion production methods are debated, with some requiring high energy and others utilizing low-energy techniques.
Previous research has introduced low-energy methods for nanoemulsion preparation, challenging the necessity of high-energy input.

Purpose of the Study:

To formulate, evaluate, and compare nanoemulsions produced via high-energy and low-energy methods.
To investigate the impact of different production energies on nanoemulsion characteristics and drug release.

Main Methods:

Low-energy method: Phase Inversion Composition (PIC) technique utilizing ternary phase diagrams.
High-energy method: High-pressure homogenization optimized using Design-Expert software and desirability function.

Main Results:

No significant difference in globule size between high-energy and low-energy nanoemulsions (p > 0.05).
Extremely significant differences in poly-dispersibility index (PDI) were observed between the two methods (p < 0.001).
Drug release profiles showed very significant differences (p < 0.001), with over 60% released in 2 hours for all formulations.

Conclusions:

Both high-energy and low-energy methods can produce nanoemulsions with comparable globule sizes.
Low-energy methods, specifically PIC, result in significant differences in PDI and drug release kinetics compared to high-energy homogenization.
Further research is needed to fully understand the implications of these differences for nanoemulsion applications.