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Homocysteine and other cardiovascular risk factors in patients with lichen planus

N Saleh1, N Samir, H Megahed

  • 1Department of Dermatology Faculty of Medicine, Cairo University, Cairo, Egypt.

Journal of the European Academy of Dermatology and Venereology : JEADV
|December 17, 2013
PubMed

Insights

Patients with lichen planus exhibit elevated cardiovascular and metabolic risk factors, including higher homocysteine and fibrinogen levels, likely due to chronic inflammation. This study highlights potential links between lichen planus and increased cardiovascular disease risk.

Area of Science:

  • Dermatology and Immunology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Chronic inflammation is implicated in cardiovascular risk factors.
  • Homocysteine and fibrinogen are independent cardiovascular disease risk factors.
  • Lichen planus is associated with dyslipidemia and potentially metabolic syndrome due to inflammatory cytokines.

Purpose of the Study:

  • To assess cardiovascular risk factors in lichen planus patients.
  • To investigate the relationship between lichen planus and metabolic syndrome parameters.

Main Methods:

  • Study included 40 lichen planus patients and 40 healthy controls.
  • Measured serum homocysteine, fibrinogen, and high-sensitive C-reactive protein (hs-CRP) using ELISA.
  • Evaluated metabolic syndrome parameters: anthropometrics, lipid profiles, blood sugar, and blood pressure.

Main Results:

  • Lichen planus patients showed significant metabolic syndrome associations (P < 0.001).
  • Elevated serum homocysteine, fibrinogen, and hs-CRP in lichen planus patients (P < 0.001).
  • Homocysteine correlated with hs-CRP and fibrinogen; fibrinogen showed a negative correlation with HDL.

Conclusions:

  • Lichen planus patients have increased metabolic and cardiovascular risk factors compared to controls.
  • Elevated risk factors are likely attributed to chronic inflammation associated with lichen planus.
  • Findings suggest lichen planus may be linked to heightened cardiovascular disease risk.
Abstract

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