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Updated: May 4, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Orbital immunoglobulin-G4-related disease: case series and literature review
Kaustubh Mulay1, Ekta Aggarwal, Mehul Jariwala
1National Reporting Centre for Ophthalmic Pathology (NRCOP), Centre for Sight, Hyderabad, India; Ophthalmic Pathology Service, L.V. Prasad Eye Institute, Hyderabad, India.
Abstract:
Immunoglobulin-G4-related disease (IgG4-RD) is a distinct group of diseases characterized by elevated serum IgG4 titres and infiltration of affected organs by IgG4-positive plasma cells. IgG4-RD can involve any ocular adnexal tissue. They have a distinct prognosis and pattern of tissue involvement and hence need to be differentiated from orbital lesions with similar clinicopathological features. We report three cases of IgG4-RD and review the literature extensively discussing various aspects of this novel entity.
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