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Apnea with RSV infection in three infants receiving palivizumab

Michael Thomas Del Vecchio1

  • 1Department of Pediatrics, Temple University School of Medicine, St Christopher's Hospital for Children, Philadelphia, Pennsylvania, USA.

Pediatrics International : Official Journal of the Japan Pediatric Society
|December 17, 2013
PubMed

Insights

Palivizumab prophylaxis may not prevent apnea in infants with respiratory syncytial virus (RSV) infections. These cases suggest apnea should still be considered in infants receiving RSV prophylaxis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatal Care

Background:

  • Respiratory syncytial virus (RSV) is a common cause of respiratory illness in infants.
  • Palivizumab is a monoclonal antibody used for RSV prophylaxis in high-risk infants.
  • RSV hospitalizations are reduced by palivizumab, but its effect on apnea is not well-established.

Observation:

  • Three infants receiving palivizumab prophylaxis presented with apnea.
  • All infants were RSV positive.
  • The infants experienced mild bronchiolitis despite palivizumab treatment.

Findings:

  • Palivizumab prophylaxis did not prevent apnea in these three RSV-infected infants.
  • Apnea associated with RSV infection can occur even with prophylaxis.

Implications:

  • Apnea in infants with RSV should be considered even when receiving palivizumab.
  • The effectiveness of palivizumab in preventing RSV-associated apnea requires further investigation.
  • Clinical management strategies for RSV-infected infants may need to account for potential apnea, regardless of prophylaxis.

Keywords:
apneapalivizumabrespiratory syncytial virus

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