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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
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Pathways of translation: deep brain stimulation.

Michael R Gionfriddo1, Alexandra J Greenberg, Abhijeet L Wahegaonkar

  • 1Mayo Graduate School, Mayo Clinic Center for Translational Science Activities, Rochester, Minnesota, USA.

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Deep brain stimulation (DBS), a neurosurgical technique, has evolved over two millennia. This review traces its unique translational path from clinical practice back to scientific research for improved therapeutic applications.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Neuroscience

Background:

  • Deep brain stimulation (DBS) is a neurosurgical technique involving high-frequency electrical current applied to targeted brain structures.
  • It is an established treatment for movement disorders and an emerging therapy for psychiatric conditions and epilepsy.

Observation:

  • The historical development of DBS reversed the typical 'bench-to-bedside' translational model.
  • Its progression from ancient practices to modern medicine was influenced by 19th-century electrical discoveries and 20th-century technological advancements.

Findings:

  • This paper reviews the historical trajectory of DBS, highlighting its unique translational journey.
  • The current research aims to understand how expanding DBS applications and enhancing outcomes are driving a return to foundational research.

Implications:

  • Understanding the reversed translational path of DBS offers insights into neurotechnology development.
  • Continued research, moving from clinical observations back to the bench, is crucial for optimizing DBS therapies and broadening its clinical utility.