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Updated: May 4, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia
Gül Eryılmaz, Gökben Hızlı Sayar1, Eylem Ozten
1Department of Psychiatry, Uskudar University, Neuropsychiatry Istanbul Hospital, Alemdag Caddesi Site Yolu No:29, Umraniye, Istanbul, Turkey. gokben.hizlisayar@uskudar.edu.tr.
Objective:
Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.
Method:
In this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.
Results:
All four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.
Conclusion:
This case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.
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