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Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific

Hilde M Storhaug, Jon V Norvik, Ingrid Toft1

  • 1Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway. Ingrid.Toft@unn.no.

BMC Cardiovascular Disorders
|December 17, 2013
PubMed

Insights

High serum uric acid levels are linked to increased risk of death and stroke in adults. This association holds even after accounting for other cardiovascular risk factors, highlighting its importance in cardiovascular health.

Area of Science:

  • Cardiovascular epidemiology
  • Metabolic health
  • Clinical risk assessment

Background:

  • The predictive role of serum uric acid for cardiovascular disease and mortality in the general population remains unclear.
  • Previous studies have shown inconsistent adjustments for cardiovascular risk factors.
  • This study investigates serum uric acid's association with mortality and major cardiovascular events, considering various risk factors.

Purpose of the Study:

  • To examine the association between serum uric acid levels and all-cause mortality.
  • To investigate the link between serum uric acid and ischemic stroke and myocardial infarction.
  • To assess these associations after adjusting for traditional and non-traditional cardiovascular risk factors.

Main Methods:

  • A population-based prospective cohort study involving 2696 men and 3004 women.
  • Follow-up periods of 15 years for mortality and 12 years for myocardial infarction and stroke.
  • Fully adjusted Cox regression analyses were employed.

Main Results:

  • Serum uric acid elevation (per 1 SD) was associated with increased all-cause mortality in both men (HR 1.11) and women (HR 1.16).
  • A 1 SD increase in serum uric acid was linked to a 22% increased risk of stroke overall (HR 1.22), with a 31% increase in men (HR 1.31).
  • No independent association was found between serum uric acid and myocardial infarction.

Conclusions:

  • Serum uric acid is independently associated with all-cause mortality in both genders, even after comprehensive risk factor adjustment.
  • Serum uric acid is independently associated with an increased risk of stroke, particularly in men.
  • These findings suggest serum uric acid is a significant predictor of cardiovascular mortality and stroke.
Abstract

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