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Updated: May 4, 2026

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells
Published on: November 7, 2025
[G protein-coupled receptors in the spot light]
Abla Benleulmi-Chaachoua1, Stefanie Wojciech1, Ralf Jockers1
1Inserm, U1016, Institut Cochin, 22 rue Méchain, 75014 Paris, France - CNRS UMR 8104, Institut Cochin, 22 rue Méchain, 75014 Paris, France - Université Paris Descartes, 12 rue de l'École de Médecine, 75006 Paris, France.
Abstract:
G protein-coupled receptors (GPCRs), also known as seven transmembrane domain-spanning proteins (7TM), play an important role in tissue homeostasis and cellular and hormonal communication. GPCRs are targeted by a large panel of natural ligands such as photons, ions, metabolites, lipids and proteins but also by numerous drugs. Research efforts in the GPCR field have been rewarded in 2012 by the Nobel Price in Chemistry. The present article briefly summarizes our current knowledge on GPCRs and discusses future challenges in terms of fundamental aspects and therapeutic applications.
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