Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Physiology01:30

Liver Physiology

3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

410
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
410
Liver Histology01:27

Liver Histology

10.7K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
10.7K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

2.7K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical evaluation of a fluorine-18-labeled indocyanine green analog for PET imaging of hepatic function.

EJNMMI radiopharmacy and chemistry·2026
Same author

Single-nucleus ATAC-seq analysis resolves chromatin and transcriptional features of fibrolamellar carcinoma.

Scientific reports·2026
Same author

Correction: DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma.

PLoS genetics·2026
Same author

β-Catenin-Cohesin Ring-CEGRs/ALCDs Axis Activation Contributes to the Development of Hepatoblastoma and Fibrolamellar HCC.

Molecular cancer research : MCR·2025
Same author

Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage.

Scientific reports·2025
Same author

A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma.

SLAS discovery : advancing life sciences R & D·2025
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

11.9K

Neonatal liver physiology.

James Grijalva1, Khashayar Vakili1

  • 1Department of Surgery, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115.

Seminars in Pediatric Surgery
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

The neonatal liver matures post-birth, impacting metabolism, detoxification, and bile synthesis. Understanding these changes is crucial for managing preterm infants at risk of complications.

Keywords:
Bile synthesisBiotransformationFatty acidGlucoseLiverMetabolismNeonatalPhysiologic jaundicePhysiology

More Related Videos

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.1K
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.2K

Related Experiment Videos

Last Updated: May 4, 2026

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

11.9K
Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.1K
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.2K

Area of Science:

  • Neonatal physiology
  • Hepatology
  • Pediatric medicine

Background:

  • The neonatal liver is functionally immature at birth.
  • Key functions include metabolism, detoxification, and bile synthesis.
  • Preterm neonates face higher risks due to liver immaturity.

Purpose of the Study:

  • To review neonatal liver function.
  • To describe the maturational changes in the neonatal liver.
  • To highlight the clinical implications of liver immaturity.

Main Methods:

  • Literature review of neonatal liver physiology.
  • Analysis of functional changes during the postnatal period.
  • Synthesis of information on clinical risks.

Main Results:

  • Neonatal liver functions (metabolism, detoxification, bile synthesis) evolve post-birth.
  • Liver immaturity poses risks like hypoglycemia, hyperbilirubinemia, and impaired drug metabolism, especially in preterm infants.
  • Maturation is essential for managing neonates needing medical or surgical care.

Conclusions:

  • Understanding neonatal liver maturation is vital for clinical practice.
  • Early postnatal liver changes influence infant health outcomes.
  • This knowledge aids in the management of vulnerable neonates.