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Ghrelin as a starvation signal
1Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan.
Summary:
Ghrelin, a gastrointestinal hormone, functions as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). It comprises 28 amino acids, of which the Ser-3 residue is post-translationally modified by the addition of octanoyl acid. Ghrelin stimulates feeding and the secretion of growth hormone; it is also thought to function in energy conservation. Here, we provide an overview of the discovery of ghrelin, its pathophysiological significance, and the mechanism of ghrelin-induced feeding.:
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