Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baroreceptor mechanisms at the cellular level.

F Sachs

    Federation Proceedings
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Baroreceptor transduction mechanisms remain unknown, but mechanotransducer ion channels offer insights. These channels use strain-dependent gating and cytoskeletal coupling for sensitive, rapid signal transduction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Kinetics and the Permeation Properties of Piezo Channels.

    Current topics in membranes·2017
    Same author

    Free Volume in Membranes: Viscosity or Tension?

    Open journal of biophysics·2016
    Same author

    Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

    Progress in biophysics and molecular biology·2011
    Same author

    Cardiac mechanosensitivity and stretch-activated ion channels.

    Trends in cardiovascular medicine·2011
    Same author

    Membrane Electromechanics in Biology, with a Focus on Hearing.

    MRS bulletin·2010
    Same author

    Thermodynamics of mechanosensitivity.

    Physical biology·2005
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    See all related articles

    Area of Science:

    • Biophysics
    • Cell Physiology
    • Mechanobiology

    Background:

    • The in vivo mechanisms and location of baroreceptor transduction are largely unknown.
    • Mechanotransducer ion channels serve as a valuable model system for studying cellular mechanosensation.

    Purpose of the Study:

    • To explore the transduction mechanisms in mechanotransducer ion channels as a model for baroreceptor function.
    • To elucidate how membrane tension is coupled to ion channel activity.

    Main Methods:

    • Investigated the role of cytoskeletal elements in concentrating membrane strain.
    • Analyzed the gating properties (strain-dependent open probability) of mechanotransducer ion channels.
    • Examined the influence of viscoelastic coupling on channel function.

    Related Experiment Videos

    Main Results:

    • Transduction in these channels occurs via a strain-dependent increase in opening probability.
    • Cytoskeletal strands concentrate strain energy from a large membrane area, ensuring high sensitivity.
    • The channel exhibits fast kinetics and lacks inactivation, though viscoelastic coupling affects its transfer function.

    Conclusions:

    • Mechanotransducer ion channels demonstrate a clear mechanism for converting mechanical stimuli into electrical signals.
    • Cytoskeletal coupling is crucial for sensitive and rapid mechanotransduction.
    • Understanding these model systems advances knowledge of sensory transduction in biological systems.