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Related Experiment Videos

Substance P and immunoregulation.

J P McGillis, M L Organist, D G Payan

    Federation Proceedings
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Substance P (SP) and vasoactive intestinal polypeptide (VIP) are nerve peptides that regulate immune responses. SP enhances lymphocyte function and immune cell activity, indicating a link between the nervous and immune systems.

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    Area of Science:

    • Neuroimmunology
    • Neuropeptide signaling
    • Mammalian physiology

    Background:

    • Peripheral nerve endings release neuropeptides like Substance P (SP) and vasoactive intestinal polypeptide (VIP).
    • These neuropeptides are key mediators of smooth muscle and vascular functions.
    • SP and VIP play significant neurophysiological roles, including nociception and interneuron excitation.

    Purpose of the Study:

    • To investigate the immunomodulatory effects of SP.
    • To explore the role of SP in hypersensitivity and inflammatory responses.
    • To characterize SP receptors on lymphocytes and understand neuro-immune system interactions.

    Main Methods:

    • Investigated SP's modulation of immediate hypersensitivity responses.
    • Assessed SP's effects on leukocyte functions (chemotaxis, enzyme release, phagocytosis).

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  • Utilized cell sorter and radioligand-binding techniques to identify SP receptors on T lymphocytes.

    • Main Results:

    • SP modulates hypersensitivity by stimulating mediator generation from mast cells.
    • SP enhances inflammatory cell functions like chemotaxis and phagocytosis.
    • SP significantly stimulates DNA, protein, and immunoglobulin synthesis in T and B lymphocytes at nanomolar concentrations.

    Conclusions:

    • SP exhibits stimulatory effects on cell-mediated immunity.
    • SP receptors are present on T lymphocytes, with ongoing efforts to isolate and characterize these proteins.
    • Understanding the SP receptor structure and gene will elucidate molecular interactions between the immune and nervous systems.