Related Experiment Video

Updated: May 4, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

11.2K

[The relationship between hyperuricemia and contrast-induced nephropathy in patients with chronic kidney disease

Yuan-Hui Liu1, Ning Tan2, Yong Liu

  • 1Graduate School, Southern Medical University,Guangzhou 510515, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|December 17, 2013
PubMed

Insights

Hyperuricemia is an independent predictor of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI). This finding highlights the importance of managing uric acid levels in this vulnerable patient population.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Disorders

Context:

  • Chronic kidney disease (CKD) patients undergoing percutaneous coronary intervention (PCI) are at high risk for contrast-induced nephropathy (CIN).
  • Hyperuricemia, a condition of elevated serum uric acid, is prevalent in CKD patients.
  • The association between hyperuricemia and CIN in this specific patient cohort remains incompletely understood.

Purpose:

  • To investigate the relationship between hyperuricemia and the incidence of CIN.
  • To identify hyperuricemia as an independent risk predictor for CIN in CKD patients undergoing PCI.

Summary:

  • A study of 446 CKD patients undergoing PCI found a significantly higher incidence of CIN in the hyperuricemic group (23.9%) compared to the normouricemic group (10.4%).
  • Hyperuricemia was identified as an independent predictor of CIN, alongside advanced age, emergent PCI, and anemia.
  • Patients with CIN experienced higher in-hospital mortality and adverse events, particularly in the hyperuricemic subgroup.

Impact:

  • This research identifies hyperuricemia as a modifiable risk factor for CIN in CKD patients undergoing PCI.
  • Findings suggest that monitoring and managing serum uric acid levels may help reduce the incidence of CIN and improve outcomes in this high-risk population.
  • The study underscores the importance of a comprehensive risk assessment for CIN, incorporating metabolic factors like hyperuricemia.
Abstract

More Related Videos

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

3.0K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.5K

Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
3.4K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
558
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
3.5K
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.4K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.3K