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Updated: May 4, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Salmonella's masterful skill in mast cell suppression
Toshiaki Kawakami1, Tomoaki Ando2
1Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama 230-0045, Japan.
Abstract:
Salmonella bacteria often cause food-borne diseases. In this issue of Immunity, Choi et al. (2013) demonstrate that the Salmonella Typhimurium-secreted protein tyrosine phosphatase, SptP, suppresses mast cell degranulation, which enables bacterial dissemination.
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