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Published on: September 18, 2013
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Update on pediatric leukemia and lymphoma imaging
Lauren W Averill1, Gunsel Acikgoz1, Robin E Miller2
1Medical Imaging, Nemours/A.I. duPont Hospital for Children, Wilmington, DE.
Seminars in Ultrasound, CT, and MR
|December 17, 2013
Summary
Pediatric leukemia and lymphoma are common childhood cancers with overlapping imaging features. This review details their classification, imaging, and treatment complications, focusing on advanced imaging techniques.
Area of Science:
- Pediatric oncology
- Diagnostic imaging
- Hematologic malignancies
Background:
- Leukemia and lymphoma constitute 50% of childhood cancers.
- These malignancies share cellular origins and can present with similar imaging findings.
- Subtype-specific variations in clinical presentation, imaging, and treatment necessitate tailored approaches.
Purpose of the Study:
- To review the classification of pediatric leukemia and lymphoma.
- To illustrate common presenting imaging findings.
- To describe staging, treatment response evaluation, and treatment-related complications.
Main Methods:
- Review of classification systems for pediatric leukemia and lymphoma.
- Illustration of characteristic imaging findings across various body systems.
- Discussion of advanced imaging modalities (e.g., PET/CT) for staging and response assessment.
- Highlighting imaging's role in identifying treatment complications.
Main Results:
- Imaging can be the initial diagnostic clue for pediatric leukemia.
- Advanced imaging like PET/CT is crucial for staging and evaluating treatment response in lymphomas.
- Imaging is vital for detecting complications associated with chemotherapy and neutropenia.
Conclusions:
- Understanding imaging features is essential for diagnosing and managing pediatric leukemia and lymphoma.
- Advanced imaging techniques improve staging and treatment monitoring.
- Future research focuses on reducing radiation exposure through novel imaging modalities.
