Related Experiment Video
Updated: May 4, 2026
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Low serum 25-hydroxyvitamin D level: an independent risk factor for tuberculosis?
Ji Hae Kim1, Jong-Sun Park2, Young-Jae Cho2
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Background & Aims:
Vitamin D deficiency has been associated with an increased risk of tuberculosis (TB). Low serum vitamin D levels may also be associated with poor nutritional status in TB patients. Therefore, this study aimed at evaluating the association between low serum vitamin D level and TB, regardless of other nutritional factors.
Methods:
Baseline serum 25-hydroxyvitamin D (25(OH)D3) levels in TB patients were measured before treatment and 1 year after treatment onset using liquid chromatography-tandem mass spectrometry, and were compared with 25(OH)D3 levels in controls. Nutritional parameters were also measured in all subjects.
Results:
In total, 165 active pulmonary TB patients and 197 controls were included in the study. Significantly higher prevalence of 25(OH)D3 insufficiency (<20 ng/mL) and deficiency (<10 ng/mL) in TB patients was showed compared to controls. Serum 25(OH)D3 levels and nutritional parameters were significantly lower in untreated TB patients than in controls. One year after TB treatment onset, nutritional parameters significantly increased; however, serum 25(OH)D3 levels in TB patients showed no significant improvement compared to baseline.
Conclusions:
These results suggest that a low serum 25(OH)D3 level might be a risk factor for TB, independent of nutritional status.
More Related Videos
08:10A Functional Whole Blood Assay to Measure Viability of Mycobacteria, using Reporter-Gene Tagged BCG or M.Tb BCG lux/M.Tb lux
Published on: September 14, 2011
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Related Concept Videos
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:23Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...