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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.8K
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30

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Related Experiment Video

Updated: May 4, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Cell based therapies for ischemic stroke: from basic science to bedside.

Xinfeng Liu1, Ruidong Ye1, Tao Yan2

  • 1Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Progress in Neurobiology
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Cell therapy shows promise for stroke recovery by replacing lost brain cells and promoting natural repair. Further research is needed to optimize cell types, delivery, and timing for human clinical application.

Keywords:
Cell-based therapiesIschemic strokeNeurorestorationStem cells

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stroke remains a leading cause of neurological disability worldwide.
  • Cell therapy offers a novel approach to neurorestoration after stroke.
  • Stem/progenitor cells are being investigated for their potential to repair brain damage.

Purpose of the Study:

  • To review preclinical and clinical evidence for cell therapy in stroke.
  • To explore various donor cell types and their restorative mechanisms.
  • To identify challenges and future directions for clinical translation.

Main Methods:

  • Comprehensive literature review of preclinical studies and clinical trials.
  • Analysis of different cell sources, delivery routes, and therapeutic mechanisms.
  • Examination of imaging strategies for in vivo cell tracking.

Main Results:

  • Transplanted cells can replace lost neural circuitry and secrete beneficial factors.
  • Stem/progenitor cells demonstrate potential in experimental and early clinical stroke studies.
  • Key issues include therapeutic window, cell selection, delivery, and monitoring.

Conclusions:

  • Cellular therapy holds significant promise for neurorestoration after stroke.
  • Addressing critical challenges is essential for successful clinical translation.
  • Further research is required to establish optimal cell-based treatment regimens.