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Polymorphic keratins in human epidermis.

D Mischke, G Wild

    The Journal of Investigative Dermatology
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Human epidermal keratins show individual variations in specific protein subunits. These variations, involving acidic and basic keratins, suggest independent allele expression and follow population distribution patterns.

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    Area of Science:

    • Biochemistry
    • Human genetics
    • Dermatology

    Background:

    • Human epidermis is composed of various keratins, essential structural proteins.
    • Previous studies identified typical keratin patterns in normal epidermis.

    Purpose of the Study:

    • To identify and compare human epidermal keratins across different individuals.
    • To investigate variations in keratin protein subunits and their genetic basis.

    Main Methods:

    • High-resolution 1D and 2D gel electrophoresis.
    • Immunoblotting techniques.
    • Analysis of keratin-enriched cytoskeletal preparations from 148 individuals.

    Main Results:

    • Identified inter-individual variations in specific basic (1a/1b, 5a/5b) and acidic (10a/10b) keratins.

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  • Keratin 14 showed no variation across all samples.
  • Observed consistent expression of keratin variants within individuals across different epithelia.
  • Variant frequencies aligned with Hardy-Weinberg predictions for population genetics.

    • Conclusions:

    • Human epidermal keratin composition exhibits genetically determined variations.
    • These variations are likely due to independent alleles for specific keratin genes.
    • The findings provide insights into keratin diversity and population genetics in human epidermis.