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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Diabetic Nephropathy01:28

Diabetic Nephropathy

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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
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Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

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PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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[Vitamin D and neuropathy].

Zsuzsanna Putz1, Tímea Martos1, Nóra Németh1

  • 1Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. u. 2/A 1083.

Orvosi Hetilap
|December 17, 2013
PubMed
Summary

Vitamin D deficiency is linked to a higher risk of diabetic neuropathy and plantar ulcers in patients with type 2 diabetes. Further research is needed to clarify these associations for better public health outcomes.

Keywords:
D-vitamindiabetes mellitusneuropathianeuropathyvitamin D

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Neurology

Context:

  • Diabetes mellitus is a global health concern with significant public health implications.
  • Vitamin D deficiency is increasingly recognized as a potential risk factor for diabetes and its complications.
  • Existing data on vitamin D levels in patients with diabetic peripheral neuropathy are limited and contradictory.

Purpose:

  • To investigate the association between vitamin D deficiency and diabetic peripheral neuropathy.
  • To explore the relationship between vitamin D deficiency and the incidence of neuropathy in type 2 diabetes.
  • To examine the potential link between vitamin D deficiency and plantar ulcer development in diabetic patients.

Summary:

  • Numerous studies suggest a correlation between vitamin D deficiency and an elevated risk of developing diabetes mellitus and its associated complications, including neuropathy.
  • Specific studies focusing on type 2 diabetes patients have corroborated the link between vitamin D deficiency and the occurrence of neuropathy.
  • Emerging evidence indicates a potential association between vitamin D deficiency and the incidence of plantar ulcers in individuals with diabetes.

Impact:

  • Clarifying the role of vitamin D in diabetic complications can inform public health strategies.
  • Understanding these relationships may lead to targeted interventions for preventing or managing diabetic neuropathy and foot ulcers.
  • This research highlights the importance of monitoring vitamin D levels in diabetic populations.