Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal ERK2 dimerization regulates inhibitory avoidance memory reconsolidation and synaptic plasticity.

iScience·2026
Same author

Hippocampal prediction errors and claustral control at the perception-memory crossroads.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

RAINSTORM: Automated Analysis of Mouse Exploratory Behavior Using Artificial Neural Networks.

Current protocols·2025
Same author

The role of the claustrum in the acquisition, consolidation and reconsolidation of memories in mice.

Scientific reports·2024
Same author

Molecular insights from the crab <i>Neohelice</i> memory model.

Frontiers in molecular neuroscience·2023
Same author

Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace.

Frontiers in molecular neuroscience·2022

Related Experiment Video

Updated: May 4, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K

Decrease of ERK/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of

Mariana Feld1, María C Krawczyk2, M Sol Fustiñana1

  • 1Laboratorio de Neurobiología de la Memoria, Dto. Fisiología, Biología Molecular y Celular, Fac. Cs. Exactas y Naturales, UBA/IFIByNE, CONICET, CABA, Argentina.

Journal of Alzheimer'S Disease : JAD
|December 17, 2013
PubMed
Summary

Early Alzheimer's disease (AD) involves memory loss due to amyloid-beta (Aβ) peptide changes. This study found that targeting the ERK pathway in mice can reverse early memory deficits, offering insights into AD progression.

Keywords:
3xTg miceAlzheimer's diseaseERKJNKNF-κBamyloid-β aggregationcalcineurinobject recognition memory

More Related Videos

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze
07:07

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze

Published on: October 29, 2019

21.0K
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

9.8K

Related Experiment Videos

Last Updated: May 4, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K
Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze
07:07

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze

Published on: October 29, 2019

21.0K
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

9.8K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • Alzheimer's disease (AD) is characterized by memory impairment, linked to amyloid-beta (Aβ) and tau pathology.
  • The precise mechanisms and early molecular alterations driving AD-related memory deficits remain under investigation.

Purpose of the Study:

  • To investigate early molecular and behavioral changes in a mouse model of AD.
  • To explore the role of specific intracellular pathways in memory impairment.

Main Methods:

  • Utilized triple-transgenic (3xTg) mice modeling human AD pathology.
  • Assessed memory function using the novel object recognition task.
  • Analyzed Aβ aggregation and intracellular pathway activity (ERK1/MAPK, JNK, NF-κB) in hippocampus and prefrontal cortex (PFC).

Main Results:

  • 3xTg mice exhibited memory impairment by 5 months of age.
  • Differential Aβ aggregation patterns were observed in the hippocampus and PFC.
  • Increased ERK1/MAPK activity was detected in the PFC, with distinct cytosolic and nuclear changes over time.

Conclusions:

  • Early memory deficits in 3xTg mice are associated with altered ERK pathway activity in the PFC.
  • Inhibiting the MEK/ERK pathway reversed memory impairment, suggesting its role in AD-related memory disruption.