Related Experiment Video
Updated: May 4, 2026
03:40
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
1.8K
Allergic disorders at a venerable age: a mini-review
1Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, Colo., USA.
Gerontology
|December 17, 2013
Summary
Allergic diseases like asthma and dermatitis affect 5-10% of older adults, with rising prevalence. Age-related immune decline and compromised barriers worsen these conditions, impacting elderly health.
Area of Science:
- Gerontology
- Immunology
- Allergology
Background:
- Prevalence of allergic diseases in the elderly is 5-10% and increasing.
- Immunosenescence and tissue changes contribute to allergic disorders in older adults.
- Elderly individuals face challenges with immune responses and epithelial barrier integrity.
Purpose of the Study:
- To review asthma, allergic rhinitis, and atopic dermatitis in the elderly.
- To discuss the impact of aging on immune function and allergic disease development.
- To highlight complications such as comorbidities and polypharmacy in elderly patients with allergies.
Main Methods:
- Literature review focusing on allergic diseases in the elderly population.
- Analysis of age-related changes in immune function and tissue structure.
- Examination of common complications and clinical presentations in older adults.
Main Results:
- Allergic diseases affect 5-10% of the elderly, with a rising trend.
- Immunosenescence and compromised epithelial barriers enhance Th2 responses.
- Undiagnosed asthma is prevalent (8%) and linked to respiratory symptoms, impacting autonomy.
Conclusions:
- Allergic disorders in the elderly are influenced by immunosenescence and tissue changes.
- Comorbidities, polypharmacy, and drug side effects are significant concerns.
- Effective management of allergic rhinitis can improve asthma control in older adults.
Related Concept Videos
02:06Allergic Reactions
26.4K
Overview
26.4K
01:15Drug Dosing: Geriatric Patients
395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
01:30Allergic Reactions: Anaphylaxis
280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367
01:27Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K